The most common and most likely answer to this crossword clue is the 5 letter word GONER
G
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More clues leading to the result GONER
- Ungrateful princess drops the Italian who is dying
- Go close, ignoring a person beyond hope?
- One who’s passed on answer abandoning approach
- He's unlikely to recover unit in Greece
- Turning up in Elsinore, no guarantee he’s doomed
- New dynamo’s housing is a hopeless case
- Move close, dislodging a person beyond help
- Committed to taking on errand, he'll depart shortly
- Good person of exceptional quality? One on the way out
- Toast and orange squash with afternoon off
Buddy explains!

The straight part
We know that "a hopeless case" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a hopeless case = goner.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does GONER mean?
GONER noun- Someone (or something) doomed; a hopeless case.