The most common and most likely answer to this crossword clue is the 8 letter word LADYBIRD
L
A
D
Y
B
I
R
D
More clues leading to the result LADYBIRD
- Spotted flyer, one badly torn, on road
- Youth given unknown sentence - one with spots
- Woman, with time in prison, spotted beetle
- Died by backing into landowner’s Beetle
- Hen possibly a dotty little creature
- Bug woman and attempt to stifle resistance
- Woman touching girlfriend leaves imprint
- Beetle for female feathered friend
- Scottish landowner touring Germany returned by Beetle
- One spotted boy by turning one way
Buddy explains!

The straight part
We know that "one with spots" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one with spots = ladybird.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does LADYBIRD mean?
LADYBIRD noun- Any of the Coccinellidae family of beetles, typically having a round shape and red or yellow spotted elytra.