The most common and most likely answer to this crossword clue is the 9 letter word LAZARETTO
L
A
Z
A
R
E
T
T
O
Buddy explains!

The straight part
We know that "locker" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case locker = lazaretto.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does LAZARETTO mean?
LAZARETTO noun- A medical facility specializing in the care for contagious patients.
- A ship or building used for quarantine.
- An area on some merchant ships where provisions are stored.