The most common and most likely answer to this crossword clue is the 5 letter word OUNCE
I've seen this crossword clue in The Times
O
U
N
C
E
More clues leading to the result OUNCE
- University pleasant after eliminating one measure
- Round relative sheds pound in weight
- Zoo unceremoniously caging leopard
- Big cat in the past seen around university
- Small amount of exuberance, head being absent
- Very light cat?
- With no pressure move to capture small portion
- Wild cat’s endless leaps
- Old relative sheds pounds? A lot less than that
- Small quantity formerly taken around university
Buddy explains!

The straight part
We know that "leopard" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case leopard = ounce.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does OUNCE mean?
OUNCE noun- An avoirdupois ounce, weighing 1/16 of an avoirdupois pound, or 28.3495 grams.
- A troy ounce, weighing 1/12 of a troy pound, or 480 grains, or 31.1035 grams.
- A US fluid ounce, with a volume of 1/16 of a US pint, 1.8047 cubic inches or 29.5735 millilitres.
- A British imperial fluid ounce, with a volume of 1/20 of an imperial pint, 1.7339 cubic inches or 28.4131 millilitres.
- A little bit.
- A large wild feline, such as a lynx or cougar.
- Now specifically, the snow leopard, Uncia uncia.