Cryptic crossword clue
16 player maybe starts to mess up string orchestration 4

The most common and most likely answer to this crossword clue is the 4 letter word MUSO

M
U
S
O

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The straight part
We know that "16 player maybe" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case 16 player maybe = muso.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MUSO mean?

MUSO noun
  1. A composer, conductor, or performer of music; specifically, a person who sings and/or plays a musical instrument as a hobby, an occupation, or a profession.

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