The most common and most likely answer to this crossword clue is the 4 plus 4 letter word BODY BLOW
B
O
D
Y
B
L
O
W
More clues leading to the result BODY BLOW
- Serious setback, as line by party taken the wrong way when in front
- Person upset by meeting deep disappointment
- Stiff wind is a serious setback
- Organisation with initially big base gets serious setback
- Throw wobbly: ingesting drug excess is a big setback
- Robert depressed about empty day, a severe setback
- Splattered bloodis serious setback
- Major upset with bloody terrible black and white films
- A serious setback! Congress starting to become insignificant
- Curse on organisation is a major setback
Buddy explains!
The straight part
We know that "A serious setback" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a serious setback = body blow.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.