Cryptic crossword clue
African runner furious as required to take in oxygen 7

The most common and most likely answer to this crossword clue is the 7 letter word MADOQUA

M
A
D
O
Q
U
A

Buddy explains!

The straight part
We know that "African runner" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case african runner = madoqua.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

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