Cryptic crossword clue
After dreadful rant writer is given drug to calm down 12

The most common and most likely answer to this crossword clue is the 12 letter word TRANQUILLISE

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "to calm down" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case to calm down = tranquillise.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TRANQUILLISE mean?

TRANQUILLISE verb
  1. To calm (a person or animal) or put them to sleep using a drug.
  2. To make (something or someone) tranquil.
  3. To become tranquil.

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