The most common and most likely answer to this crossword clue is the 11 letter word CLIMACTERIC
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More clues leading to the result CLIMACTERIC
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The cryptic/wordplay part
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What does CLIMACTERIC mean?
CLIMACTERIC noun- A critical stage or decisive point; a turning point.
- A period in human life in which some great change is supposed to take place, calculated in different ways by different authorities (often identified as every seventh or ninth year).
- The period of life that leads up to and follows the end of menstruation in women; the menopause.
- Pertaining to any of several supposedly critical years of a person's life.
- Critical or crucial; decisive.
- Relating to a period of physiological change during middle age; especially, menopausal.
- Climactic.