Cryptic crossword clue
Best, once again, note, to study inquiry briefly 9

The most common and most likely answer to this crossword clue is the 9 letter word RECONQUER

I've seen this crossword clue in The Times
R
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The straight part
We know that "Best, once again" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case best, once again = reconquer.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RECONQUER mean?

RECONQUER verb
  1. To conquer again.

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