Cryptic crossword clue
Bottle, second imbibed, making one up-beat 5

The most common and most likely answer to this crossword clue is the 5 letter word ARSIS

A
R
S
I
S

Buddy explains!

The straight part
We know that "up-beat" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case up-beat = arsis.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ARSIS mean?

ARSIS noun
  1. The stronger part of a musical measure: the part containing the beat.
  2. The stronger part of a metrical foot: the part containing the long (heavy) syllable in quantitative meter, or the stressed syllable in a qualitative meter.
  3. The elevation of the hand, or that part of the bar at which it is raised, in beating time; the weak or unaccented part of the bar, opposed to the thesis.
  4. The elevation of the voice to a higher pitch in speaking.

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