Cryptic crossword clue
Combination of melodies from nocturne I opt to change 12

The most common and most likely answer to this crossword clue is the 12 letter word COUNTERPOINT

I've seen this crossword clue in The Daily Telegraph
C
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Buddy explains!

The straight part
We know that "Combination of melodies" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case combination of melodies = counterpoint.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does COUNTERPOINT mean?

COUNTERPOINT noun
  1. A melody added to an existing one, especially one added to provide harmony whilst each retains its simultaneous identity; a composition consisting of such contrapuntal melodies.
  2. Any similar contrasting element in a work of art.
  3. An opposite point.
COUNTERPOINT verb
  1. To compose or arrange such music.
  2. To serve as an opposing point against.
COUNTERPOINT noun
  1. The topmost covering of a bed, often functioning as a blanket; a coverlet.

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