Cryptic crossword clue
Comic miss, one of four here 4

The most common and most likely answer to this crossword clue is the 4 letter word SIMS

I've seen this crossword clue in The Guardian
S
I
M
S

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SIMS mean?

SIMS noun
  1. A simulation or simulator.

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