Cryptic crossword clue
Commute into Acapulco due to work

The most common and most likely answer to this crossword clue is the 12 letter word OCCUPATIONAL

I've seen this crossword clue in The Times
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Buddy explains!

The straight part
We know that "due to work" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case due to work = occupational.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OCCUPATIONAL mean?

OCCUPATIONAL adjective
  1. Of, belonging or relating to an occupation (in any sense).

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