The most common and most likely answer to this crossword clue is the 9 letter word VARIEGATE
I've seen this crossword clue in The Guardian
V
A
R
I
E
G
A
T
E
More clues leading to the result VARIEGATE
Buddy explains!
The straight part
We know that "Create difference" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case create difference = variegate.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does VARIEGATE mean?
VARIEGATE verb- To add variety to something.
- To change the appearance of something, especially by covering with patches or streaks of different colour.
- To dapple.
- Variegated