Cryptic crossword clue
Difficult area within South American river’s mouth part 4,6

The most common and most likely answer to this crossword clue is the 4 plus 6 letter word HARD PALATE

H
A
R
D
P
A
L
A
T
E

Buddy explains!

The straight part
We know that "mouth part" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case mouth part = hard palate.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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