Cryptic crossword clue
Disease often connected to small cow or chicken 3

The most common and most likely answer to this crossword clue is the 3 letter word POX

P
O
X

Buddy explains!

The straight part
We know that "Disease" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case disease = pox.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does POX mean?

POX noun
  1. A disease characterized by purulent skin eruptions that may leave pockmarks.
  2. Syphilis.
  3. A curse.
POX verb
  1. To infect with the pox, or syphilis.

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