Cryptic crossword clue
Do least well: stop taking malt extract containing sulphur 4,3,5

The most common and most likely answer to this crossword clue is the 4 plus 3 plus 5 letter word COME OFF WORST

I've seen this crossword clue in The Times
C
O
M
E
O
F
F
W
O
R
S
T

Buddy explains!

The straight part
We know that "Do least well" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case do least well = come off worst.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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