Cryptic crossword clue
Doctor amuses with a quote about one being hardly audible 5,2,1,5

The most common and most likely answer to this crossword clue is the 5 plus 2 plus 1 plus 5 letter word QUIET AS A MOUSE

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Buddy explains!

The straight part
We know that "hardly audible" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case hardly audible = quiet as a mouse.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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