Cryptic crossword clue
Doctor sat in for matron for a change

The most common and most likely answer to this crossword clue is the 14 letter word TRANSFORMATION

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "change" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case change = transformation.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TRANSFORMATION mean?

TRANSFORMATION noun
  1. The act of transforming or the state of being transformed.
  2. A marked change in appearance or character, especially one for the better.
  3. The replacement of the variables in an algebraic expression by their values in terms of another set of variables; a mapping of one space onto another or onto itself; a function that changes the position or direction of the axes of a coordinate system.
  4. A rule that systematically converts one syntactic form into another; a sentence derived by such a rule.
  5. The alteration of a bacterial cell caused by the transfer of DNA from another, especially if pathogenic.
  6. Ideologically driven government policy - becoming more conformant with socialist and African nationalist groupthink.

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