Cryptic crossword clue
Friendly relations leaving area infested with insects 4

The most common and most likely answer to this crossword clue is the 4 letter word MITY

M
I
T
Y

Buddy explains!

The straight part
We know that "infested with insects" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case infested with insects = mity.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

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