The most common and most likely answer to this crossword clue is the 5 plus 3 plus 5 plus 4 letter word BRING THE HOUSE DOWN
I've seen this crossword clue in The Times
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More clues leading to the result BRING THE HOUSE DOWN
Buddy explains!
The straight part
We know that "Get a big hand" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case get a big hand = bring the house down.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.