Cryptic crossword clue
Grandchild lacking blood group system developed protection 8

The most common and most likely answer to this crossword clue is the 8 letter word CLADDING

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Buddy explains!

The straight part
We know that "protection" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case protection = cladding.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CLADDING mean?

CLADDING verb
  1. (past tense clad) To clothe.
  2. (past tense clad or cladded) To cover (with insulation or another material); to surround, envelop.
  3. (figuratively) To imbue (with a specified quality)
CLADDING noun
  1. Clothing; clothes.
  2. Any hard coating, bonded onto the outside of something to add protection, such as the plastic sheath around an optical fibre.
  3. A weatherproof, insulating or decorative covering fixed to the outside of a building (called siding in the US).

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