The most common and most likely answer to this crossword clue is the 7 plus 5 letter word WRITERS BLOCK
I've seen this crossword clue in The Daily Telegraph
W
R
I
T
E
R
S
B
L
O
C
K
Buddy explains!
The straight part
We know that "a hindrance to creative work" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a hindrance to creative work = writers block.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.