Cryptic crossword clue
Make every possible effort in Lorna’s flat first? 2,4,5,4

The most common and most likely answer to this crossword clue is the 2 plus 3 letter word DO ONE

I've seen this crossword clue in The Daily Telegraph
D
O
O
N
E


Buddy explains!

The straight part
We know that "Make every possible effort" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case make every possible effort = do one.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions


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