The most common and most likely answer to this crossword clue is the 4 plus 3 plus 4 letter word TURN THE TIDE
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More clues leading to the result TURN THE TIDE
Buddy explains!
The straight part
We know that "Make the difference/Canute couldn’t?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case make the difference/canute couldn’t? = turn the tide.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.