Cryptic crossword clue
No going back after mastermind confronts strong desire for doctor 5,7

The most common and most likely answer to this crossword clue is the 5 plus 7 letter word BRAIN SURGEON

B
R
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N
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N

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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