Cryptic crossword clue
Old government department, weary of discussion, relocated to Defra 5,2,5

The most common and most likely answer to this crossword clue is the 5 plus 2 plus 5 letter word BOARD OF TRADE

I've seen this crossword clue in Financial Times
B
O
A
R
D
O
F
T
R
A
D
E

Buddy explains!

The straight part
We know that "Old government department" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case old government department = board of trade.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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