Cryptic crossword clue
… one of 26 22 down’s daughters, starting to head out of Czech city 2,2

The most common and most likely answer to this crossword clue is the 2 plus 2 letter word DR NO

I've seen this crossword clue in The Guardian
D
R
N
O

Buddy explains!

The straight part
We know that "one of 26 22 down’s" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one of 26 22 down’s = dr no.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

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