Cryptic crossword clue
Plymouth has a complex temperature controller 12

The most common and most likely answer to this crossword clue is the 12 letter word HYPOTHALAMUS

I've seen this crossword clue in The Times
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Buddy explains!

The straight part
We know that "temperature controller" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case temperature controller = hypothalamus.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HYPOTHALAMUS mean?

HYPOTHALAMUS noun
  1. A region of the forebrain located below the thalamus, forming the basal portion of the diencephalon, and functioning to regulate body temperature, some metabolic processes and governing the autonomic nervous system.

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