Cryptic crossword clue
Pope’s observation hurts: Rome in a flap 2,3,2,5

The most common and most likely answer to this crossword clue is the 2 plus 3 plus 2 plus 5 letter word TO ERR IS HUMAN

I've seen this crossword clue in The Times
T
O
E
R
R
I
S
H
U
M
A
N

Buddy explains!

The straight part
We know that "Pope’s observation" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case pope’s observation = to err is human.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Latest crossword clues with full explanations