Cryptic crossword clue
Popular exam in English ultimately takes guts 10

The most common and most likely answer to this crossword clue is the 10 letter word INTESTINES

I
N
T
E
S
T
I
N
E
S

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The straight part
We know that "guts" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case guts = intestines.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INTESTINES mean?

INTESTINES noun
  1. (often pluralized) The alimentary canal of an animal through which food passes after having passed all stomachs.
  2. One of certain subdivisions of this part of the alimentary canal, such as the small or large intestine in human beings.

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