Cryptic crossword clue
Prague hostelry, we’re told, will offer desk to register 5-2

The most common and most likely answer to this crossword clue is the 8 letter word CHECK-IN

I've seen this crossword clue in The Times
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Buddy explains!

The straight part
We know that "desk to register" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case desk to register = check-in.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CHECK-IN mean?

CHECK-IN noun
  1. The act of checking in at a hotel, airport, etc.
  2. The submission of source code or other material to a source control repository.

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