Cryptic crossword clue
Prank on the Queen makes one very cross 5

The most common and most likely answer to this crossword clue is the 5 letter word RAGER

I've seen this crossword clue in The Guardian
R
A
G
E
R

Buddy explains!

The straight part
We know that "one very cross" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one very cross = rager.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RAGER mean?

RAGER noun
  1. One who rages.
  2. A party, particularly a large, wild party (social event).
  3. A raging erection; a massive erection of the penis.

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