Cryptic crossword clue
Public transporter totally empty, big up top? 5

The most common and most likely answer to this crossword clue is the 5 letter word BUSTY

I've seen this crossword clue in Financial Times
B
U
S
T
Y

Buddy explains!

The straight part
We know that "big up top?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case big up top? = busty.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does BUSTY mean?

BUSTY adjective
  1. Having large breasts.

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