Cryptic crossword clue
Sedate Latin rule is designed to cover question 12

The most common and most likely answer to this crossword clue is the 12 letter word TRANQUILLISE

I've seen this crossword clue in The Daily Telegraph
T
R
A
N
Q
U
I
L
L
I
S
E

Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TRANQUILLISE mean?

TRANQUILLISE verb
  1. To calm (a person or animal) or put them to sleep using a drug.
  2. To make (something or someone) tranquil.
  3. To become tranquil.

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