The most common and most likely answer to this crossword clue is the 7 letter word ISOMERS
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Buddy explains!
The straight part
We know that "chemicals with same molecular weight but different arrangement of atoms/chemical" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case chemicals with same molecular weight but different arrangement of atoms/chemical = isomers.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ISOMERS mean?
ISOMERS noun- Any of two or more compounds with the same molecular formula but with different structure.
- Any of two or more atomic nuclei with the same mass number and atomic number but with different radioactive properties.