Cryptic crossword clue
Small spot about to be taken up in intestinal area 5

The most common and most likely answer to this crossword clue is the 5 letter word CELOM

C
E
L
O
M

Buddy explains!

The straight part
We know that "intestinal area" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case intestinal area = celom.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CELOM mean?

CELOM noun
  1. A fluid-filled cavity within the body of an animal. The digestive system is suspended within the cavity, which is lined by a tissue called the peritoneum.

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