Cryptic crossword clue
Starts a trial of quiet routes touring southeast Cuba

The most common and most likely answer to this crossword clue is the 10 letter word PROSECUTES

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "Starts a trial" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case starts a trial = prosecutes.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PROSECUTES mean?

PROSECUTES verb
  1. To start criminal proceedings against.
  2. To charge, try.
  3. To seek to obtain by legal process.
  4. To pursue something to the end.

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