Cryptic crossword clue
Such philosophers exalt sin — it is set to explode 15

The most common and most likely answer to this crossword clue is the 15 letter word EXISTENTIALISTS

I've seen this crossword clue in The Daily Telegraph
E
X
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S
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N
T
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A
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EXISTENTIALISTS mean?

EXISTENTIALISTS noun
  1. A person who adheres to the philosophy of existentialism.

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