Cryptic crossword clue
Suffering after picking up undergarment with an arachnid 10

The most common and most likely answer to this crossword clue is the 10 letter word HARVESTMAN

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Buddy explains!

The straight part
We know that "arachnid" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case arachnid = harvestman.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HARVESTMAN mean?

HARVESTMAN noun
  1. A field-worker who works to gather in the harvest.
  2. An order of terrestrial, non-venomous arachnids with often very long legs: Opiliones.

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