Cryptic crossword clue
They took care of Caligula etc using a drug preparation quietly dropped in a cocktail 10,5

The most common and most likely answer to this crossword clue is the 10 plus 5 letter word PRAETORIAN GUARD

P
R
A
E
T
O
R
I
A
N
G
U
A
R
D

Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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