Cryptic crossword clue
Tired of hearing Nessun dorma? An appropriate response! 2,2,5

The most common and most likely answer to this crossword clue is the 2 plus 2 plus 5 letter word GO TO SLEEP

I've seen this crossword clue in Financial Times
G
O
T
O
S
L
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P

Buddy explains!

The straight part
We know that "An appropriate response" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case an appropriate response = go to sleep.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

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