Cryptic crossword clue
Tissue — one bit in the middle of supermarket is put into cart 4,6

The most common and most likely answer to this crossword clue is the 4 plus 6 letter word BONE MARROW

I've seen this crossword clue in The Daily Telegraph
B
O
N
E
M
A
R
R
O
W

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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