Cryptic crossword clue
U-U-U-U like some meat? That’s a huge blow! 6,6

The most common and most likely answer to this crossword clue is the 6 plus 6 letter word DOUBLE WHAMMY

I've seen this crossword clue in The Guardian
D
O
U
B
L
E
W
H
A
M
M
Y

Buddy explains!

The straight part
We know that "a huge blow" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a huge blow = double whammy.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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