Cryptic crossword clue
Unknown East Ender’s assistant, one emitting shrill cries 6

The most common and most likely answer to this crossword clue is the 6 letter word YELPER

I've seen this crossword clue in The Times
Y
E
L
P
E
R

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The straight part
We know that "one emitting shrill cries" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one emitting shrill cries = yelper.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

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