Cryptic crossword clue
Who’s not to be trusted, nastier than rascal?

The most common and most likely answer to this crossword clue is the 10 letter word CHARLATANS

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Buddy explains!

The straight part
We know that "Who’s not to be trusted" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case who’s not to be trusted = charlatans.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CHARLATANS mean?

CHARLATANS noun
  1. A mountebank, someone who addresses crowds in the street; (especially), an itinerant seller of medicines or drugs.
  2. A malicious trickster; a fake person, especially one who deceives for personal profit.

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