Cryptic crossword clue
Boundaries set up by male — that’s unfair to females 6

The most common and most likely answer to this crossword clue is the 6 letter word SEXISM

I've seen this crossword clue in The Sunday Telegraph
S
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X
I
S
M

Buddy explains!

The straight part
We know that "unfair to females" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case unfair to females = sexism.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SEXISM mean?

SEXISM noun
  1. The belief that people of one sex or gender are inherently superior to others.
  2. Discrimination or different treatment (e.g. in job opportunities) based on sex or gender.
  3. Attitudes or actions that are based on or promote the expectation that people adhere to stereotypical social roles (gender roles) based on sex.

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